Meet Paul Isaac ’23, an OUR Peer Research Ambassador (PRA) majoring in Molecular & Cell Biology and Diagnostic Genetic Sciences, and minoring in Bioinformatics.
What is the focus of your research?
Horseshoe crab blood contains proteins that have high affinity to bacteria and fungi. For this reason, the pharmaceutical industry has been bleeding these crabs to create a sterility test used on most biomedical devices and drugs. My research is focused on sequencing and analyzing the genome of the North Atlantic Horseshoe crab (Limulus polyphemus) to study the genes behind these clotting proteins to eventually create a synthetic version of this sterility test and eliminate the need for bleeding practices.
Why did you get involved in research?
Ever since I was diagnosed as being color-blind at age 6, I’ve been curious about genetics and how genetic technology and theory is applied. In high school, my biology teacher taught us about genetic engineering through a basic transfection experiment that made a bacteria fluorescent. In the moment I thought, “if we could add a gene to make bacteria glow, what if we could add a gene that could “fix” disorders or help other organisms?”. I googled the concept and was bombarded by a slew of literature by researchers working towards that same goal. Wanting to pursue and contribute to that ideal at UConn is what led me to design my first formal research project and my PI’s amazing personality and mentorship have helped me turn those projects into a passion to not be a bystander to progress, but to actively contribute to it through research. Continue reading