Meet Krithika Santhanam ’25, an OUR Peer Research Ambassador (PRA) double majoring in Molecular & Cell Biology and Health Policy & Racial Disparities (individualized major).
What is the focus of your research?
The long bones of the adult arms and legs are originally completely made of cartilage. During embryonic development and adolescence, nearly all of the cartilage disappears and becomes replaced by bone through a process called endochondral ossification. The critical step of endochondral ossification is chondrocyte maturation; A stepwise differentiation program in which the chondrocytes that comprise the cartilage of the long bones proliferate, enlarge in size, and ultimately change into bone.
A key signal that promotes chondrocyte differentiation during maturation is the BMP (bone morphogenetic protein) pathway; A critical positive regulator of chondrocyte differentiation during maturation, however which individual BMP factor(s) mediate this role and their influence on promoting proliferation and/or stem cell behaviors are unknown. My project aims to identify a new chondrocyte population that emerges below the growth plate and into the bone marrow space by using markers to identify their properties. My project provides insight into how understanding signals that control the balance of stemness and differentiation may help restore articular cartilage loss in adults by stimulating cartilage growth.
Why did you get involved in research?
In all honesty, I got involved in research because it was something I saw high-achieving individuals pursing around me. As a Freshman, I wondered if I would be able to write a research proposal, present at a conference, and go through the experimental design process. I wanted to engage in this process to learn more about myself and try something new. Once I found a project I was passionate about, digging deeper into my work came naturally and going through difficult processes like applying for SURF, creating a poster, and experimental design allowed me to grow valuable skills of presentation, communication, and collaboration which is what I hoped for going into the experience. Continue reading