Meet Krithika Santhanam ’25 an OUR Peer Research Ambassador double majoring in Molecular & Cell Biology and Individualized: Health Policy & Racial Disparities.
What is the focus of your research?
The long bones of the adult arms and legs are originally completely made of cartilage. During embryonic development and adolescence, nearly all of the cartilage disappears and becomes replaced by bone through a process called endochondral ossification. The critical step of endochondral ossification is chondrocyte maturation; A stepwise differentiation program in which the chondrocytes that comprise the cartilage of the long bones proliferate, enlarge in size, and ultimately change into bone.
A key signal that promotes chondrocyte differentiation during maturation is the BMP (bone morphogenetic protein) pathway; A critical positive regulator of chondrocyte differentiation during maturation, however which individual BMP factor(s) mediate this role and their influence on promoting proliferation and/or stem cell behaviors are unknown. My project in the Dealy Lab aims to identify a new chondrocyte population that emerges below the growth plate and into the bone marrow space by using markers to identify their properties. My project provides insight into how understanding signals that control the balance of stemness and differentiation may help restore articular cartilage loss in adults by stimulating cartilage growth. Continue reading