Project Mentor
Dr. Brian Kelley
Department of Neurosurgery
Undergraduate Research Opportunity Description
| Project Description | This project focuses on blood-meningeal barrier responses to traumatic brain injury. Using an animal model of concussive injury, the student would investigate cellular and molecular changes in neurovascular composition within the meninges following injury. The student would be responsible for tissue processing, immunohistochemistry, microscopic image acquisition, and quantitative analyses of meningeal blood vessels and fibroblasts in control and experimental groups. |
| Project Direction | The laboratory focuses on post-traumatic changes within the meninges following mild traumatic brain injury (TBI) / concussion mediated by diffuse injury forces. Not much is known regarding topographic meningeal changes following diffuse TBI although more recent research implicates the meninges as a key mediator of neuroinflammatory responses. The long-term goals are to understand cellular responses at molecular and genetic levels that may lead to treatment strategies designed to mitigate post-traumatic detrimental consequences. |
| Mentorship and Supervision | Training in scientific techniques will be provided along with appropriate supervision. Meetings with the PI will occur most days to discuss progress and troubleshoot problematic issues. Project goals and timelines will be developed at the beginning of the rotation to ensure the student remains on track to complete their requirements. Feedback will be provided directly to the student. |
| Student Qualifications | Ideal qualifications include previous experience with tissue processing, immunohistochemistry, confocal microscopy including image acquisition, and quantitative analyses including biostatistics. However, these skills are not prerequisites for the position. Training can be offered in these skills as part of the experience. |
| Summer Schedule Options | Research Dates: May 19 to July 25, 2025 Schedule: The laboratory is available weekdays from 9 AM – 6 PM. Weekend time can be established if necessary. |
| Project Continuation | Fall 2025, Spring 2026 |
| Academic Year Time Commitment | 3-6 hours/week |
| Possible Thesis Project | Yes |
Application
Submit an online application for this research opportunity at https://quest.uconn.edu/prog/HRPSU25-15. The application deadline is Monday, February 17, 2025.
This application requires a resume or CV, a brief statement of research interests, a brief statement of career interests, and references.