Project Mentor

Dr. Mallika Ghosh
Department of Center for Vascular Biology

Undergraduate Research Opportunity Description

Project Description	Cell-cell fusion is a highly specialized process mediated by fusion regulatory proteins involved in a variety of diverse cellular functions. CD13, a transmembrane protein that we study in my lab, controls many events including adhesion, migration, membrane organization, and endocytosis which are critical in cell-cell fusion. We hypothesize that CD13 is a negative regulator of cell-cell fusion during osteoclastogenesis and macrophage giant cell formation, and thus is a novel target for therapeutic intervention in pathological conditions mediated by defects in cell-cell fusion such as osteoporosis and failure of medical implants such as hernia mesh, glucose sensors, stents, and many medical devices.
Project Direction	During the summer, the student will learn about the project, read literature related to the project and research techniques such as cell culture, cell-based assay, imaging and microscopy, and eventually how to perform implant surgery in mice. During the academic year, since the student will be spending limited time in the lab, I will advise to focus on goals that can be achieved during that time. For example, the student can analyze data that was gathered during the summer research, focus on histology, immunohistochemistry, and microscopy of sections that were obtained during the summer research, write manuscripts, and present research at conferences.
Mentorship and Supervision	Perform assigned readings of scientific papers on related topics. Observe procedures performed by mentor and lab members Perform experimental procedures under the guidance of the mentor Have regular communication and feedback about procedures and techniques with the mentor daily. Follow protocols written and develop new protocols for new procedures used. Reflection Journal & Lab Notebook Presentations in Center and Lab Meetings Present Poster and research at fall Spring UConn Frontiers in Undergraduate Research Fair Application to fellowships including SURF, Idea Grant Have meetings with the mentor about opportunities to gain experience and guidance on career options. Apply for several fellowships including: Undergrad Fellowship Programs and American Society for Cell Biology Travel undergraduate fellowship for participating in the upcoming ASCB conferences
Student Qualifications	Coursework in Biological sciences and Chemistry will be helpful but not mandatory. Specific skills will be taught during the summer research.
Summer Schedule Options	Research Dates: May 19 to July 25, 2025 Schedule: Mon-Fri, 9AM-5PM
Project Continuation	Fall 2025
Academic Year Time Commitment	3 hours/week
Possible Thesis Project	Yes

Application

Submit an online application for this research opportunity at https://quest.uconn.edu/prog/HRPSU25-10. The application deadline is Monday, February 17, 2025.

This application requires a cover letter, a resume or CV, an unofficial transcript, GPA and Science GPA a brief statement of research interests, and a brief statement of career interests. References should be available upon request.