Project Mentor
Dr. Dong Zhou
Department of Medicine
Undergraduate Research Opportunity Description
| Project Description | This summer project will investigate how extracellular matrix protein 1 (ECM1) determines the progression of kidney fibrosis. We have found that deletion of ECM1 caused animal death at age 8-10 weeks due to spontaneous organ fibrosis. However, very few studies pay attention to the exact role of this protein in the kidney. Therefore, we will investigate the mechanisms of how ECM1 involved in chronic kidney disease progression. The applicant will need to perform in vivo, in vitro, ex vivo experiments and learn the skills of bioinformatic analysis for the generated proteomics data in this project to understand the picture of kidney fibrosis. |
| Project Direction | The main research focus in our lab is the formation of the tissue microenvironment and organ repair. This summer project is the main part of our new research program: ECM1-organized kidney microenvironment mediates the transition from AKI to renal fibrosis. Successful completion of this summer project will significantly contribute to the progress of the entire program. |
| Mentorship and Supervision | 1. First, we will teach the applicant what kidney disease is from the aspects of the clinic and basic science. 2. Second, we will train the applicant on how to design a frame of the scientific projects for kidney disease. 3. Third, we will train the applicant to master necessary experimental techniques, including making buffers or gels for experiments, PCR, Western blot assay, immunostaining, and bioinformatics. 4. Fourth, we will assist the applicant in summarizing the research project, preparing the presentation, and publishing the study. |
| Student Qualifications |
Coursework completed/in progress: Cell Biology, Statistics Academic interests related to kidney/liver diseases.
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| Summer Schedule Options | Monday-Friday 9 am through 5 pm for 10 weeks. |
| Project Continuation | Fall 2024, Spring 2025 |
| Academic Year Time Commitment | 6 hours/week – 9 hours/week |
| Possible Thesis Project | Yes |
Application
Submit an online application for this research opportunity at https://quest.uconn.edu/prog/HRP24-41. The application deadline is Monday, January 29, 2024.
This application requires a Cover Letter, Resume or CV, GPA, Science GPA, Statement of Qualifications, Statement of Research Interests, Statement of Career Interests, and References.