Project Mentor

Dr. Royce Mohan
Department of Neuroscience

Undergraduate Research Opportunity Description

Project Description	Two broad projects are available for study. One encompasses research related to AMD using genetically altered mice and drug treatments to support a means to block fibrosis and restore normal healing. In the second project also using transgenic mice, we are investigating corneal Schwann cell (cSC) responses to a range of injuries and studying how cSCs control axonal growth and sensory recovery in the cornea.
Project Direction	Over 10 million Americans suffer from a retinal disease known as age-related macular degeneration (AMD). We have discovered a novel mechanism that contributes to retinal fibrosis in AMD and are currently investigating therapeutics as anti-fibrotic agents. My lab also studies injury to the eye and is working towards identifying mechanisms of corneal pathology, therapeutic targets and treatments to support injury healing and regeneration. In this second project, we have identified also a novel mechanism by which corneal Schwann cells contribute to axonal regeneration and thus support the restoration of sensory function in the cornea.
Mentorship and Supervision	All students will receive mentorship and supervision by the PI and also by an Assistant Professor in the Mohan lab. They will be trained and supervised in their techniques and afforded opportunities to expand their scientific knowledge and technical skills that prepare them for futures in biomedical, neuroscience and medical career paths. There is a one-on-one interaction, so faculty will be hands facilitators for advising and mentorship.
Student Qualifications	Students will be expected to gain technical knowledge on mouse handling, ability to perform eye injury in the cornea or laser injury in the retina. In addition to these in vivo experiments, they will also isolate and examine eye tissues using immunostaining and western blot experiments. Those who have some or more of these experimental skills will be preferred, but not necessarily a limitation as if they are willing to learn these techniques with be taught in the lab.
Summer Schedule Options	Typically, students will be in the lab M-F from 9am -5/6 pm over the 10 week period. On occasion, they may have to come in on a weekend. The time devoted after hours or weekends will be counted towards the 360 hours of research.
Project Continuation	Fall 2024, Spring 2025
Academic Year Time Commitment	6-9 hours/week
Possible Thesis Project	Yes

Application

Submit an online application for this research opportunity at https://quest.uconn.edu/prog/HRP24-22. The application deadline is Monday, January 29, 2024.

This application requires a Resume or CV, Cover Letter, Science GPA, Statement of Qualifications, Statement of Research Interests, and Statement of Career Interests. References should be available upon request.