Project Mentor

Dr. Yuan Gui
Department of Medicine/Nephrology

Undergraduate Research Opportunity Description

Project Description	The project explores how Coronin 1A remodels inflammatory microenvironment and dictates acute kidney injury (AKI) prognosis. We will subject AKI models, including ischemia-reperfusion injury (IRI) and cisplatin injection, to WT and coronin 1A knockout mice to evaluate AKI outcomes after coronin 1A deletion. Besides, global/phosphor-proteomics will performed to explore the underlying mechanism.
Project Direction	Macrophage and T-cell-mediated immune response is a critical mechanism in AKI onset. Coro 1A is markedly induced in the kidneys after AKI, and it is highly expressed in macrophages and T cells to regulate immune cell activation, migration, and phagocytosis. In this project, we will explore whether coronin 1A plays a role in AKI.
Mentorship and Supervision	I will train the students one-on-one for about two weeks. Then I will let the students do some experiments independently and provide guidance anytime.
Student Qualifications	The students may be interested in acute kidney injury research. In the program, the students mainly do some bench research, including western blot gel, cell culture, genotype PCR, Immunohistochemistry (IHC) staining, and Immunofluorescence (IF) staining.
Summer Schedule Options	Monday-Friday 10:00 am to 5:00 pm
Project Continuation	Fall 2024, Spring 2025
Academic Year Time Commitment	3-6 hours/week
Possible Thesis Project	Yes

Application

Submit an online application for this research opportunity at https://quest.uconn.edu/prog/HRP24-13. The application deadline is Monday, January 29, 2024.

This application requires a Cover Letter, Resume or CV, Statement of Qualifications, and GPA. Names and contact information for references should be provided in the application.