Project Mentor

Dr. Andres Grosmark
Department of Neuroscience

Undergraduate Research Opportunity Description

Project Description	As the world population ages Alzheimer’s disease (AD) has gained epidemic proportions, yet our understanding of the precise mechanisms by which AD leaves specific memories vulnerable to forgetting remain unclear. One type of memory that is profoundly affected by AD is long-term spatial memory. In my lab students will have the opportunity to help develop, test and implement 3D virtual reality devices built specifically for testing long-term spatial memory on mouse models for AD. Students with backgrounds in coding/computer science and/or biology are encouraged to apply.
Project Direction	Assisting in setting up this VR system will be instrumental in allowing us to probe the circuits of long-term memory deficits in Alzheimer’s disease (AD). The VR-based paradigms will be used in conjunction with two-photon calcium imaging of large populations of hippocampal neurons and electrophysiology to determine how ensembles of cells form memory-supporting circuits, and how these circuits malfunction in AD.
Mentorship and Supervision	1) The student will be provided with the background literature and with hands on training directly from the PI, with additional supervision by experienced lab members while performing experiments, 2) The student is expected to join journal clubs and lab meetings to further understand the context and process of their project, 3) The student will have at least weekly meetings with the PI to discuss their progress and future directions. 4) The student will be expected to keep detailed notes of their work which will be discussed together with the PI, 5) Feedback will be provided at the weekly meetings and through other lab communications such as through the Teams messaging app.
Student Qualifications	Strong communication and organizational skills and the ability to learn new techniques are important characteristics for the position. Students with a background in either coding (i.e. Python, Matlab or C++) or with experience in working with laboratory mice are strongly encouraged to apply.
Summer Schedule Options	Monday-Friday 9 am through 5 pm.
Project Continuation	Fall 2024, Spring 2025
Academic Year Time Commitment	6-9 hours/week
Possible Thesis Project	Yes

Application

Submit an online application for this research opportunity at https://quest.uconn.edu/prog/HRP24-12. The application deadline is Monday, January 29, 2024.

This application requires a Cover Letter, Resume or CV, GPA, Statement of Qualifications, and Statement of Research Interests. References should be available upon request.