Project Mentor

Dr. Tannin Schmidt
Department of Biomedical Engineering

Undergraduate Research Opportunity Description

Project Description	Lubricin is a multifunctional protein, with both lubricating and anti-inflammatory properties, that is present throughout the human body. While initially discovered and studied in synovial fluid as a lubricant of joints, we recently discovered it in tears, the ocular surface, and in the posterior of the eye. Recombinant human lubricin has been shown to be clinically effective in treating dry eye disease, improving signs and symptoms of dry eye disease in humans. This project will examine the biological (anti-inflammatory) properties of recombinant human lubricin in the context of disease(s) related to the eye.
Project Direction	This project will contribute to an overall goal of understanding the mechanism of action of lubricin on the ocular surface and in the posterior of the eye. This work leverages the unique availability of full length recombinant human lubricin for study, made available from the clinical stage biotechnology company Lubris BioPharma, which is being evaluated and developed as a therapeutic for other clinical applications.
Mentorship and Supervision	I will schedule one-on-one weekly meetings with the student to discuss upcoming experimental plans, as well as results from the previous week. Training will consist of experimental planning, execution, documentation, as well as data interpretation and presentation. The student will work closely with a PhD student in the lab and get direct, hands-on experience with biomedical engineering techniques. Constructive feedback will be provided on a weekly basis as well. Lastly, I also have an open-door policy so that the student can come meet with me in my office, which is right across the hall from the lab, as much as needed.
Student Qualifications	No specific qualifications are required. All undergrad students with an interest in biomedical engineering and sciences will be considered, with a preference for students who have completed at least two years of their program.
Summer Schedule Options	Research Dates: May 22 to July 28, 2023 Schedule: To be arranged within schedule parameters of M-F, 9am-6pm
Project Continuation	Fall 2023, Spring 2024
Academic Year Time Commitment	9 hours/week
Possible Thesis Project	Yes

Application

Submit an online application for this research opportunity at https://quest.uconn.edu/prog/HRP23-33. The application deadline is Monday, January 30, 2023.

This application requires a cover letter, a resume or CV, an unofficial transcript, GPA, science GPA, a brief statement of research interests, and a brief statement of career interests. Names and contact information (phone and/or email) for two references should be provided in the application.