Dr. Leslie Loew
Center for Cell Analysis and Modeling
Undergraduate Research Opportunity Description
|Project Description||The lab is using computational methods to understand cell function. The project will involve learning how to use a cell modeling software tool that was developed in my lab called SpringSaLaD (https://vcell.org/ssalad). You will use it to understand the molecular and cellular principles controlling the assembly of molecular machines composed of many individual molecules containing multiple binding sites. If you are interested in computer programming, there will also be the opportunity to work on improving SpringSaLaD.|
|Project Direction||We are particularly interested in predicting the essential properties of the molecules that interact to form machines. What features of the molecules allow molecules to reliably and robustly assemble into functional biological nano-machines?
For the software project, we are developing user-friendly software to allow biophysicists to understand complex multi-molecular assembly processes.
|Mentorship and Supervision||I will touch base with the student on a daily basis and have a comprehensive progress discussion weekly. My door is always open and all my students are encouraged to “bother me” when questions arise. I also plan to partner the student with an advanced graduate student in my lab who is working on a similar research project. Periodically, the student will be asked to present an inform progress report at my lab meetings. At the end of the summer, there will be an opportunity for the student to present her/his progress to the entire Center.|
|Student Qualifications||Courses in Physical chemistry or biophysical chemistry. For the software project, experience programmming in Python and/or Java.|
|Summer Schedule Options||Research Dates: May 24 to July 30, 2021
Schedule: M-F, 8am-6pm (flexible)
|Project Continuation||Fall 2021, Spring 2022|
|Academic Year Time Commitment||6 hours/week|
|Possible Thesis Project||Yes|
Submit an online application for this research opportunity at https://quest.uconn.edu/prog/HRP21-19. The application deadline is Monday, February 1, 2021.
This application requires a cover letter, a resume or CV, an unofficial transcript, a brief statement of research interests, and contact information for references.