Project Mentor

Dr. Rosa Guzzo
Department of Neuroscience

Undergraduate Research Opportunity Description

Project Description	The focus of my research is understanding the epigenetic regulation in the development of the endochondral skeleton. We have identified a novel role for Dot1L, a chromatin modifier, in cartilage development and joint morphogenesis. Mice lacking expression of this gene in embryonic development exhibit a unique skeletal dysplasia phenotype. Research projects in my laboratory will utilize novel animal models systems of genetic loss of Dot1L function, primary cell cultures, differentiation assays, transcriptome analysis and chromatin assays to define the developmental and epigenetic contribution of Dot1L in embryonic and postnatal development.
Project Direction	Mis-regulation of cartilage and bone formation and growth can lead to various forms of skeletal dysplasia, which manifest in short stature, bone and joint malformations, and painful complications that reduce quality of life. The molecular regulation of endochondral ossification and genetic basis of skeletal dysplasia have been intensively studied, yet our understanding of the epigenetic modifiers in normal skeletal development and growth is still emerging. Our in vivo models of Dot1L loss of function provide a tractable system useful for interrogating the underlying epigenetic basis of defects seen in skeletal dysplasia.
Mentorship and Supervision	Students in the laboratory will be trained, supervised, and mentored directly by the PI. The PI will provide necessary reading materials, and will meet regularly with the student to discuss training goals and research objectives. Weekly laboratory meetings will define milestones, assess progress, and provide an opportunity to troubleshoot experiments, discuss data analysis, and interpret results.
Student Qualifications	Candidates should have a genuine interest in biological research, and be highly motivated to learn new concepts and techniques. Laboratory experience is preferred, but not mandatory.
Summer Schedule Options	Research Dates: May 24 to July 30, 2021 Schedule: M-F, 9am-5pm
Project Continuation	Fall 2021, Spring 2022
Academic Year Time Commitment	6-9 hours/week
Possible Thesis Project	Yes

Application

Submit an online application for this research opportunity at https://quest.uconn.edu/prog/HRP21-16. The application deadline is Monday, February 1, 2021.

This application requires an unofficial transcript and a brief statement of career interests.