Project Mentor

Dr. Ping Yan
Center for Cell Analysis and Modeling (Department of Cell Biology)

Undergraduate Research Opportunity Description

Project Description	There is a summer research opportunity for a chemistry student to synthesize new voltage sensitive dyes (VSDs). While mainly working on organic syntheses, the student will also measure the absorption and fluorescence spectra, test the sensitivities in artificial membranes, and possibly image action potential in real cells using newly synthesized VSDs (in collaboration with Dr. Loew).
Project Direction	The long term goal of this research is to make faster, brighter, and more sensitive and specific voltage sensitive dyes for fluorescence imaging of functions in brains and hearts. Currently we are working on highly sensitive VSDs that can target specific cells using HaloTag technology.
Mentorship and Supervision	For the first 1-2 weeks, I will train the student on basic safety, synthetic skills, and various instruments such as NMR. Later on, I will monitor progress and provide feedback at least once every other day.
Student Qualifications	The incoming student should have completed at least one semester of organic chemistry and one semester of organic chemistry laboratory.
Summer Schedule Options	Research Dates: May 26 to July 31, 2020 Schedule: M-F, 9am-5pm
Project Continuation	Fall 2020, Spring 2021
Academic Year Time Commitment	6 hours/week
Possible Thesis Project	Yes

Application

Submit an online application for this research opportunity at https://quest.uconn.edu/prog/HRP20-28. The application deadline is Monday, February 3, 2020.

This application requires a cover letter, a resume or CV, an unofficial transcript, and contact information for references.