Project Mentor

Dr. Tannin Schmidt
Department of Biomedical Engineering

Undergraduate Research Opportunity Description

Project Description	Lubricin is multi functional protein, with both lubricating and anti inflammatory properties, that is present throughout the human body. In particular, lubricin is present in synovial fluid as well as tears, and is critical for both knee joint and ocular surface health. Recombinant human lubricin has been shown to be effective in treating osteoarthritis in preclinical models, and also improving signs and symptoms of dry eye disease in humans. This project will examine the regulation of lubricin biosynthesis by various relevant cell types, as well as further explore lubricin’s recently discovered anti-inflammatory properties.
Project Direction	This project will contribute to an overall goal of understanding the mechanism of action of lubricin on the ocular surface and in cartilage. This work leverages the availability of full length recombinant human lubricin for study, made available from the clinical stage biotechnology company Lubris BioPharma, which is being evaluated and developed as a therapeutic for other clinical applications.
Mentorship and Supervision	I will schedule one-on-one weekly meetings with the student to discuss upcoming experimental plans, as well as results from the previous week. Training will consist of experimental planning, execution, documentation, as well as data interpretation and presentation. The student will work closely with a PhD student in the lab and get direct hands on experience with biomedical engineering techniques. Constructive feedback will be provided on a weekly basis as well. Lastly, I also have an open-door policy so that the student can come meet with me in my office, which is right across the hall from the lab, as much as needed.
Student Qualifications	No specific qualifications are required. All undergrad students with an interest in biomedical engineering and sciences will be considered, with a preference for students who have completed at least two years of their program.
Summer Schedule Options	Research Dates: May 26 to July 31, 2020 Schedule: M-F, 9am-5pm
Project Continuation	Fall 2020, Spring 2021
Academic Year Time Commitment	9 hours/week
Possible Thesis Project	Yes

Application

Submit an online application for this research opportunity at https://quest.uconn.edu/prog/HRP20-22. The application deadline is Monday, February 3, 2020.

This application requires a cover letter, a resume or CV, an unofficial transcript, a brief statement of research interests, a brief statement of career interests, and contact information for references.