Project Mentor
Dr. Leslie Loew
Berlin Center for Cell Analysis and Modeling
Undergraduate Research Opportunity Description
| Project Description | The lab is using computational methods to understand cell function. The project will involve learning how to use a cell modeling software tool that was developed in my lab called SpringSaLaD (https://vcell.org/ssalad). You will use it to understand the molecular and cellular principles controlling the assembly of molecular machines composed of many individual molecules containing multiple binding sites. If you are interested in computer programming, there will also be the opportunity to work on improving SpringSaLaD. |
| Project Direction | We are interested in the principles that control how biological molecules assemble into functional higher order structures. Such structures can be highly rigid machines, small dynamic clusters or large aggregates or droplets big enough to see with a light microscope. The goal is to understand what controls which of these classes of multi-molecular systems is produced, given the biochemistry of the interacting molecules and their state in the cell. |
| Mentorship and Supervision | I will meet with the student at her/his desk daily for at least a brief update. Once each week, we will have a thorough discussion of progress in my office. I will be available any time when the student needs to consult with me. The student will participate in biweekly lab meetings and the weekly CCAM Research in Progress meeting. At the end of the summer, the student will prepare a powerpoint summary of his/her research and present it to the CCAM Research in Progress. |
| Student Qualifications | A course in Physical Chemistry or Biophysics A course in Calculus Computer Programming experience (optional) |
| Summer Schedule Options | Research Dates: May 26 to July 31, 2020 Schedule: M-F, 8am-5pm. Because this is a computational project, it may be possible for the student to spend some time working remotely. |
| Project Continuation | Fall 2020, Spring 2021 |
| Academic Year Time Commitment | 6 hours/week |
| Possible Thesis Project | Yes |
Application
Submit an online application for this research opportunity at https://quest.uconn.edu/prog/HRP20-14. The application deadline is Monday, February 3, 2020.
This application requires a resume or CV, an unofficial transcript, and a brief statement of research interests.