HRP SU19-4: Research Opportunity with Dr. Bojun Chen

Project Mentor

Dr. Bojun Chen
Neuroscience

Undergraduate Research Opportunity Description

Project Description This project is to identify genes that play important roles in controlling the reproductive lifespan in the nematode C. elegans. We have a C. elegans strain with a doubled reproductive lifespan. Using this strain, we plan to perform a genetic screen to isolate mutants that restore the normal reproductive lifespan.
Project Direction How the reproductive lifespan is controlled and associated with aging in animals is an important biological question. Through performing genetic screens in the animal model C. elegans, this project will identify genes that regulate reproductive lifespan, and provide new insights into the genetic regulation of reproductive senescence and its potential association with organism longevity.
Mentorship and Supervision I will first introduce the animal model C. elegans to the student, and let the student read some books and literature about C. elegans. Meanwhile I will teach the student how to grow and maintain C. elegans. Next, I will train the student to perform a behavior-based genetic screen. I will check the putative mutants that the student isolated from the screen, and work with student to group the mutants through complementation test. If the student is interested in continuing the project into the academic year, it may serve as the student’s thesis project. I will guide the student to map a candidate gene and dissect its role in regulating reproductive lifespan.
Student Qualifications Students with basic biological knowledge and interest in biology are encouraged to apply.
Summer Schedule Options Research Dates: May 28 to August 2, 2019
Schedule: M-F, 9am-5pm or 9am-4pm (if student using shuttle service)
Project Continuation Fall 2019, Spring 2020
Academic Year Time Commitment 6 hours/week
Possible Thesis Project Yes

Application

Submit an online application for this research opportunity at https://quest.uconn.edu/prog/HRP19-4/. The application deadline is Monday, February 4, 2019.

This application requires a cover letter and a resume or CV.