Project Mentor

Dr. Ji Yu
Center for Cell Analysis and Modeling

Undergraduate Research Opportunity Description

Project Description	Two projects are available for summer students: 1. To design, synthesize and evaluate new fluorescent molecular probes that specifically label phosphotyrosines in cells. Perform various imaging assays using the fluorescent probes on model systems, and compare their relative performance. 2. To perform computational analyses of super-resolution imaging data using novel software developed in the lab. Evaluate the performance of the algorithm.
Project Direction	Tyrosine phosphorylation is a reversible post-translational modification of proteins that regulates protein activities and protein localization during signal transduction. Misregulation of tyrosine phosphorylation is the hallmark of many diseases, particularly cancer. The lab is interested in developing imaging based methods to assay signal transduction states in normal and diseased tissues by profiling single-cell phosphoproteome.
Mentorship and Supervision	– Student will have weekly individual research meeting with PI – Student is expected to present in lab meeting periodically – Student will present his/her research work at least once in a departmental seminar – A Graduate student / postdoc from the lab will train the student for 2-4 weeks on bench techniques related to the project
Student Qualifications	Any students that are currently pursuing a science/engineering degree can apply
Summer Schedule Options	Research Dates: May 28 to August 2, 2019 Schedule: M-F, 9am-5pm
Project Continuation	Fall 2019, Spring 2020
Academic Year Time Commitment	9 hours/week
Possible Thesis Project	Yes

Application

Submit an online application for this research opportunity at https://quest.uconn.edu/prog/HRP19-29/. The application deadline is Monday, February 4, 2019.

This application requires a resume or CV and GPA.