Project Mentor

Dr. Zhao-Wen Wang
Neuroscience

Undergraduate Research Opportunity Description

Project Description	We recently discovered that C. elegans AIPR-1, a homolog of human aryl hydrocarbon receptor-interacting protein, is a strong regulator of neurotransmitter release, and functions through stabilizing the calcium releasing channel ryanodine receptor in the endoplasmic reticulum membrane (Chen et al., Nat Commun 2017). We would like to identify proteins that are important to AIPR-1 function in vivo using a forward genetic approach. Specifically, the student will screen for mutant worms that suppress a behavioral phenotype caused by AIPR-1 deficiency.
Project Direction	The mutant genes will be subsequently identified through genetic mapping and whole-genome sequencing. We will determine whether and how the identified genes contribute to AIPR-1 function using a variety of other approaches.
Mentorship and Supervision	We will train the student to pick worms, make worm culture plates, and screen mutant worms. The isolated mutants will be evaluated through visual inspection and electrophysiological experiments by other lab members. We will provide feedback to the student through frequent conversations.
Student Qualifications	We are looking for a highly motivated student in a biology-related major. We hope that the student is a good observer so that relatively subtle behavioral differences between mutant worms and the original worms may be detected by eye.
Summer Schedule Options	Research Dates: May 28 to August 2, 2019 Schedule: To be arranged between 9am-6pm, M-F
Project Continuation	Fall 2019, Spring 2020
Academic Year Time Commitment	3-9 hours/week
Possible Thesis Project	Yes

Application

Submit an online application for this research opportunity at https://quest.uconn.edu/prog/HRP19-24. The application deadline is Monday, February 4, 2019.

This application requires a resume or CV, an unofficial transcript, and a brief statement of research interests.