Project Mentor

Dr. Tannin Schmidt
Biomedical Engineering

Undergraduate Research Opportunity Description

Project Description	Lubricin is a lubricating molecule recently discovered on the eye and in tears that is important for ocular surface health. Recombinant human lubricin has been shown to be clinically effective in improving signs and symptoms of dry eye disease, and is also able to adsorb to commercial contact lenses and reduce friction. This project will examine the biochemical and biomechanical regulation of lubricin biosynthesis by ocular surface cells, and subsequent interaction with contact lenses and contact lens biomaterials. Recently discovered anti-inflammatory properties of lubricin will also be examined within the context of ocular surface cells and tissues.
Project Direction	This project will contribute to an overall goal of understanding the mechanism of action of lubricin on the ocular surface, as well as potential use to improve comfort of commercial contact lenses. This work leverages the availability of full length recombinant human lubricin for study, made available from the clinical stage biotechnology company Lubris BioPharma, which is being evaluated and developed as a therapeutic for other clinical applications.
Mentorship and Supervision	I will schedule one-on-one weekly meetings with the student to discuss upcoming experimental plans, as well as results from the previous week. Training will consist of experimental planning, execution, documentation, as well as data interpretation and presentation. The student will work closely with a research technician in the lab and get direct hands on experience with biomedical engineering techniques. Constructive feedback will be provided on a weekly basis as well. Lastly, I also have an open-door policy so that the student can come meet with me in my office, which is right across the hall from the lab, as much as needed.
Student Qualifications	No specific qualifications are required. All undergrad students with an interest in biomedical engineering and sciences will be considered, with a preference for students who have completed at least two years of their program. Minimum GPA: 3.2. Minimum Science GPA: 3.2.
Summer Schedule Options	Research Dates: May 29 – August 3, 2018 Schedule: A shuttle-supported work schedule from Storrs, Monday to Friday 9am-4pm, will be accommodated. However, if the student elects to use other modes of transportation or make housing arrangements close to UConn Health, other time blocks can be accommodated as well.
Project Continuation	Fall 2018, Spring 2019
Academic Year Time Commitment	9 hours/week
Possible Thesis Project	Yes

Application

Submit an online application for this research opportunity using the form below. The application deadline is Friday, January 26, 2018.

This application requires a cover letter, a resume or CV, an unofficial transcript, a brief statement of research interests, and a brief statement of career interests.