Project Mentor

Dr. Danielle Rux
Department of Orthopedic Surgery

Undergraduate Research Opportunity Description

Project Description	We are interested in understanding mechanisms that drive the development of synovial joints and articular cartilage, the cushion that prevents damage to articulating bones. The selected student will learn to perform PCR, tissue histology, staining and imaging techniques from a novel genetically modified mouse model to test molecular mechanisms that control articular cartilage growth and maturation during embryonic and postnatal development.
Project Direction	Our primary goal is to answer fundamental questions related to the development of articular cartilage. Our research will enhance knowledge of joint disease/injury where innate tissue regeneration is minimal, and treatments are short-term. Tissue regeneration often copies many aspects of normal development; thus, a deeper understanding of these mechanisms is key to informing new treatments. The summer project is expected to produce preliminary findings on a novel developmental mechanism for articular cartilage that will continue to be tested throughout the academic year.
Mentorship and Supervision	The student will be trained and supervised directly by the PI and also by senior lab members. They will also participate in weekly lab meetings where they will present their progress and they will also meet weekly 1:1 with the PI where additional guidance and support will be tailored to meet the needs of the student. At the midpoint of the program, progress will be evaluated, and changes will be discussed to enhance the experience and progress of the student in the second half.
Student Qualifications	The candidate must be willing to work in a research lab where laboratory animals (mice) are used as a model system to study tissue development and disease. There are no specific qualifications to be successful in the role, however the following qualifications may be preferred: coursework in basic biology/molecular biology, strong organizational and communication skills, flexibility of skills and mind, and a commitment to research integrity.
Summer Schedule Options	Research Dates: May 19 to July 25, 2025 Schedule: Monday-Friday 9am through 6pm
Project Continuation	Fall 2025, Spring 2026
Academic Year Time Commitment	6 hours/week
Possible Thesis Project	Yes

Application

Submit an online application for this research opportunity at https://quest.uconn.edu/prog/HRPSU25-24. The application deadline is Monday, February 17, 2025.

This application requires a cover letter, a resume or CV, GPA, and a brief statement of career interests. References should be available upon request.