Project Mentor

Dr. Sangamesh Kumbar
Orthopaedic Surgery

Undergraduate Research Opportunity Description

Project Description	Students will be involved in one of two projects: Project 1. Design, fabrication and characterization of polymeric micro-nanostructures for tissue engineering applications. Micro-nanostructures fabrication will utilize 3D printing and advanced electrospinning techniques to design scaffolds for the repair and regeneration of neural and tendon tissues. Scaffolds will be optimized for physicochemical properties in terms of mechanical strength, degradation, and pore and surface properties. Project 2. Polymeric nano-particles for therapeutic and diagnostic applications. We have synthesized and characterized novel fluorescent polymers for this application. Students working on this project will work on per-formulation studies focused on improving the solubility of poorly soluble drugs to improve their bioavailability. Students will learn fabrication, characterization of nano-particles for physico-chemical properties, and drug release behavior.
Project Direction	Project 1. The micro-nano-structured matrices will be tested for their ability to support adult stem cell attachment, proliferation and differentiation into neural and tendon tissue under the influence of growth factors or physical stimulation. Protocols for these characterization have been optimized and studies will repeat the initial findings and move the project forward. Project 2. Drug encapsulated nano-formulations will be tested for bioactivity and toxicity using in vitro cell culture experiments. Optimized conditions and formulations will be applied to specific disease conditions and address specific questions for the drug delivery perspective.
Student Qualifications	Project 1. Primary working knowledge in cell culture, molecular biology, and related course work. Strong desire to learn additional techniques required for the project. Project 2. Committed students with strong background in biomaterials and molecular biology techniques are highly encouraged to apply. Course work in these areas is expected.
Time Commitment	9 hours/week
Schedule Options	Open to establishing schedule convenient for student.
Project Continuation	Summer 2017 and/or Fall 2017
Possible Thesis Project	Yes

Application

Submit an online application for this research opportunity using the form below. The application deadline is Friday, January 6, 2017.

This application requires a cover letter, a resume or CV, an unofficial transcript, a brief statement of research interests, and a brief statement of career interests.