Project Mentor
Dr. Anne Delany
Center for Molecular Medicine
Undergraduate Research Opportunity Description
Project Description | We use in vitro and in vivo models understand how specific microRNAs (miRNAs, small non-coding RNAs) control the biology of osteoclasts (bone resorbing cells) and osteoblasts (bone forming cells). Projects available for the Spring include understanding how over expression or knockdown of a specific miRNA can alter the differentiation and function of osteoblasts or osteoclasts. Studies will be performed in vitro, using cell lines transduced with lentivirus. In addition, the function of specific miRNAs in vivo will be examined using transgenic mouse models, in which skeletal phenotyping will be performed. Techniques to be used include cell culture, Western blot analysis, qRT-PCR, and histology. |
Project Direction | In the Summer and the Fall, the project will continue along the same line of inquiry, probing deeper into the molecular mechanisms regulating miRNA expression and bone cell biology. Not much is known about the function of miRNAs in the skeleton, and this is a critical area of investigation. Our research will contribute to the understanding of basic bone biology, as well as provide a rationale for miRNA-based therapeutics for the treatment of skeletal disease. |
Student Qualifications | Applicants should be highly motivated, with a strong work ethic and an good understanding of basic biology principles. Minimum Science GPA: 3.2. |
Time Commitment | 6-9 hours/week |
Schedule Options | All work should be performed Monday-Friday, 9 AM through 6 PM. A minimum of 3 consecutive hours is required to make progress on research tasks. |
Project Continuation | Summer 2017 and/or Fall 2017 |
Possible Thesis Project | Yes |
Application
Submit an online application for this research opportunity using the form below. The application deadline is Friday, January 6, 2017.
This application requires a resume or CV, an unofficial transcript, and a brief statement of career interests.