Project Mentor
Dr. Dong Zhou
Department of Medicine
Undergraduate Research Opportunity Description
| Project Description | This summer project will investigate how the immune cell–expressed G-protein-coupled receptor Smoothened (Smo) influences the outcome of acute kidney injury (AKI). Our published work has shown that deletion of Smo in fibroblasts attenuates AKI severity by creating a more favorable microenvironment. However, despite the central role of immune cells in shaping the AKI microenvironment, very few studies have examined the specific function of immune cell–derived Smo in renal injury and repair. To address this critical gap, this project aims to elucidate the mechanisms by which immune cell–expressed Smo regulates AKI onset, progression, and resolution. The student will gain hands-on experience with in vivo, in vitro, and ex vivo experimental approaches, and will develop foundational bioinformatic skills to analyze proteomic datasets generated during the study. Through this integrative research experience, the student will develop a comprehensive understanding of immune-tubule interactions in AKI and the molecular pathways controlled by Smo signaling in kidney injury. |
| Project Direction | The main research focus of our lab is understanding how kidney microenvironments form and how they regulate organ repair. This summer project represents a central component of our new research program, which investigates how Smo-organized kidney microenvironments mediate the onset and progression of AKI. Successful completion of the project will provide key mechanistic insights and substantially advance the overall program. |
| Mentorship and Supervision | 1. First, we will teach the applicant what kidney disease is from the aspects of the clinic and basic science. 2. Second, we will train the applicant on how to design a frame for the scientific projects for kidney disease. 3. Third, we will train the applicant to master necessary experimental techniques, including making buffers or gels for experiments, PCR, Western blot assay, immunostaining, and bioinformatics. 4. Fourth, we will assist the applicant in summarizing the research project, preparing the presentation, and publishing the study. |
| Student Qualifications | Coursework completed/in progress: Cell Biology Academic interests related to kidney or other organ diseases. |
| Summer Schedule Options | Research Dates: May 18 to July 24, 2026 Schedule: Monday - Friday 9AM - 5PM |
| Project Continuation | Fall 2026, Spring 2027 |
| Academic Year Time Commitment | 3-9 hours/week |
| Possible Thesis Project | Yes |
Application
Submit an online application for this research opportunity at https://quest.uconn.edu/prog/HRP26-43. The application deadline is Monday, February 16, 2026.
This application requires a Cover Letter, Resume or CV, GPA and Science GPA, Statement of Research Interests, Statement of Career Interests, and 3 References: Contact Information: Name, title, phone number, and email address.