Project Mentor
Dr. Danielle Rux
Department of Orthopedic Surgery
Undergraduate Research Opportunity Description
| Project Description | Our central research question is: how do developmental mechanisms that shape tissues early in life continue to influence tissue health and vulnerability to disease across the lifespan? The Rux lab focuses these efforts on the synovial joints and articular cartilage that are essential for all ranges of motion, but that are also highly susceptible to diseases such as arthritis that significantly reduce quality of life. Ongoing research projects are focused on how hedgehog signaling and the Hox genes function in joint development and disease. The selected student will learn to perform PCR, tissue histology, staining and imaging techniques from a novel genetically modified mouse model to test molecular mechanisms that control articular cartilage growth and maturation during embryonic and postnatal development. |
| Project Direction | The summer project is designed to generate preliminary data for an ongoing research project that will continue throughout the academic year. Work completed over the summer is expected to contribute to future publications and grant submissions and may also be developed into an undergraduate thesis project. |
| Mentorship and Supervision | The student will be trained and supervised directly by the PI and also by senior lab members. They will also participate in weekly lab meetings where they will present their progress and they will also meet weekly 1:1 with the PI where additional guidance and support will be tailored to meet the needs of the student. At the midpoint of the program, progress will be evaluated, and changes will be discussed to enhance the experience and progress of the student in the second half. |
| Student Qualifications | The candidate must be willing to work in a research lab where laboratory animals (mice) are used as a model system to study tissue development and disease. While there are no specific qualifications to be successful in the role, preferred qualifications include coursework in basic biology/molecular biology; demonstrated strong organizational and communication skills; the ability to follow instructions; and a genuine interest in basic scientific research. |
| Summer Schedule Options | Research Dates: May 18 to July 24, 2026 Schedule: Monday-Friday 8/9am through 5/6pm |
| Project Continuation | Fall 2026, Spring 2027 |
| Academic Year Time Commitment | 6,9 hours/week |
| Possible Thesis Project | Yes |
Application
Submit an online application for this research opportunity at https://quest.uconn.edu/prog/HRPSU26-30. The application deadline is Monday, February 16, 2026.
This application requires a cover letter, a resume or CV, and GPA. References should be available upon request.