Project Mentor
Dr. Baihai Jiao
Department of Medicine
Undergraduate Research Opportunity Description
| Project Description | This summer research opportunity focuses on investigating the molecular mechanisms underlying chronic kidney disease (CKD), with particular emphasis on kidney fibrosis and necroptosis signaling. The project will examine the role of casein kinase 1 alpha (CK1α) in regulating receptor-interacting protein kinase 3 (RIPK3)–mediated pathways that contribute to tubular injury, inflammation, and fibrotic remodeling in the kidney. Students will gain hands-on experience in experimental techniques including cell culture, gene expression analysis, PCR, real-time RT-PCR, Western blotting, immunohistochemistry, immunofluorescence, and histological analysis to elucidate key molecular mechanisms. This research aims to identify novel therapeutic targets for CKD while providing students with valuable training in biomedical research and translational science. |
| Project Direction | The summer project contributes to a broader research effort aimed at elucidating the molecular mechanisms driving kidney fibrosis in chronic kidney disease (CKD). This work is part of an ongoing investigation into necroptosis-associated signaling, with a particular focus on the CK1α–RIPK3 axis and its role in promoting renal inflammation and fibrotic remodeling. Findings from this project will inform continued mechanistic and translational studies during the academic year to identify potential therapeutic targets for CKD. |
| Mentorship and Supervision | I will provide hands-on training and gradually increase the research assistant's responsibilities. Their progress will be monitored through weekly check-ins to discuss results and challenges. I will offer feedback during these meetings and remain available for ongoing support as needed. |
| Student Qualifications | Students should have a basic understanding of biology and an interest in kidney disease research. We welcome hardworking and motivated individuals who are eager to learn and contribute to the project. |
| Summer Schedule Options | Research Dates: May 18 to July 24, 2026 Schedule: Monday to Friday, 9 AM to 5 PM, with flexibility to adjust based on individual preferences. |
| Project Continuation | Fall 2026 |
| Academic Year Time Commitment | 3, 6, or 9 hours/week |
| Possible Thesis Project | Yes |
Application
Submit an online application for this research opportunity at https://quest.uconn.edu/prog/HRPSU26-17. The application deadline is Monday, February 16, 2026.
This application requires a resume or CV.