Project Mentor
Dr. Xiaoyan Guo
Department of Department of Genetics and Genome Sciences
Undergraduate Research Opportunity Description
| Project Description | Our lab focus on elucidating organelle quality control mechanisms. The accumulation of dysfunctional mitochondria is closely linked to various diseases, including neurodegenerative disorders. Our research focuses on uncovering the molecular and cellular mechanisms that maintain mitochondrial health. Using CRISPR-based genetic screening, we have identified candidate genes involved in this process. This summer project offers students an exciting opportunity to investigate these genes and explore their roles in regulating mitochondrial health. |
| Project Direction | Once the functional roles of the genetic hits in regulating mitochondrial quality control are validated, students will have the opportunity to continue with molecular mechanistic studies beyond the summer. |
| Mentorship and Supervision | The summer student will receive direct mentorship from both the Principal Investigator (PI) and a graduate student in the lab. Daily meetings will be held to discuss the project, review relevant papers, and provide hands-on training in technical skills. The student will also have the opportunity to present their work at lab meetings, where constructive feedback will be offered through regular, daily interactions. |
| Student Qualifications | Students with a strong interest in molecular and cellular biology, specifically organelle quality control mechanisms, are highly recommended to join our lab. |
| Summer Schedule Options | Research Dates: May 18 to July 24, 2026 Schedule: Monday-Friday 9am-6pm |
| Project Continuation | Fall 2026, Spring 2076 |
| Academic Year Time Commitment | 6, 9 hours/week |
| Possible Thesis Project | Yes |
Application
Submit an online application for this research opportunity at https://quest.uconn.edu/prog/HRPSU26-16. The application deadline is Monday, February 16, 2026.
This application requires a cover letter, a resume or CV, an unofficial transcript, GPA and science GPA, a brief statement of research interests, a brief statement of career interests, and references.