Project Mentor
Dr. Yuan Gui
Department of Medicine/Nephrology
Undergraduate Research Opportunity Description
| Project Description | The project explores how Coronin 1A remodels the kidney fibrotic microenvironment. We will subject CKD models, including ischemia-reperfusion injury (IRI), low-dose cisplatin injection, and Unilateral Ureteral Obstruction (UUO) to WT and Coronin 1A knockout mice to evaluate kidney fibrosis after Coronin 1A deletion. Besides, global/phosphoproteomics will be performed to explore the underlying mechanism. |
| Project Direction | The project explores how Coronin 1A remodels the kidney fibrotic microenvironment. We will subject CKD models, including ischemia-reperfusion injury (IRI), low-dose cisplatin injection, and Unilateral Ureteral Obstruction (UUO) to WT and Coronin 1A knockout mice to evaluate kidney fibrosis after Coronin 1A deletion. Besides, global/phosphoproteomics will be performed to explore the underlying mechanism. |
| Mentorship and Supervision | I will train the students one-on-one for about two weeks. Then I will let the students do some experiments independently and provide guidance anytime. |
| Student Qualifications | The students may be interested in kidney fibrosis. In the program, the students mainly do some bench research, including Western blot gel, cell culture, genotype PCR, Immunohistochemistry (IHC) staining, and Immunofluorescence(IF) staining. |
| Summer Schedule Options | Research Dates: May 18 to July 24, 2026 Schedule: Monday-Friday 10:00 am to 5:00 pm |
| Project Continuation | Fall 2026, Spring 2027 |
| Academic Year Time Commitment | 3-6 hours/week |
| Possible Thesis Project | Yes |
Application
Submit an online application for this research opportunity at https://quest.uconn.edu/prog/HRPSU26-14. The application deadline is Monday, February 16, 2026.
This application requires a cover letter, a resume or CV, GPA, and references.