Project Mentor

Dr. Dong Zhou
Department of Medicine/Nephrology

Undergraduate Research Opportunity Description

Project Description	This summer project aims to explore the role of Microfibrillar-associated protein 2 (MFAP2) in the onset and progression of acute kidney injury (AKI). Our preliminary findings indicate that global deletion of MFAP2 exacerbates AKI, but the precise mechanisms remain unclear. The applicant will investigate these mechanisms through in vivo, in vitro, and ex vivo experiments. Additionally, the applicant will acquire bioinformatics skills to analyze proteomics data generated throughout the project, providing a comprehensive understanding of the molecular landscape involved in AKI.
Project Direction	Our lab’s primary research focus is the formation of the tissue microenvironment and its role in organ repair. This summer project is a key component of our research on matrix proteins and the tissue microenvironment in AKI. Successfully completing this project will make a significant contribution to advancing the overall goals of our program.
Mentorship and Supervision	1. Introduction to Kidney Disease: The applicant will first be taught about kidney disease from both clinical and basic science perspectives. 2. Scientific Project Design: The applicant will be trained in designing a scientific framework for kidney disease research, including hypothesis development and experimental planning. 3. Experimental Techniques: The applicant will gain hands-on experience with essential experimental techniques, including buffer and gel preparation, PCR, Western blotting, immunostaining, and bioinformatics analysis. 4. Project Summary and Publication: Finally, the applicant will be guided in summarizing the research, preparing presentations, and working toward publishing the findings.
Student Qualifications	Coursework completed/in progress: Cell Biology, Statistics Academic interests related to kidney/liver diseases.
Summer Schedule Options	Research Dates: May 19 to July 25, 2025 Schedule: Monday-Friday 9 am through 5 pm for 10 weeks.
Project Continuation	Fall 2025, Spring 2026
Academic Year Time Commitment	3, 6, or 9 hours/week
Possible Thesis Project	Yes

Application

Submit an online application for this research opportunity at https://quest.uconn.edu/prog/HRPSU25-40. The application deadline is Monday, February 17, 2025.

This application requires a cover letter, a resume or CV, GPA and science GPA, a brief statement of research interests, a brief statement of career interests, and references.