Project Mentor

Dr. Rajkumar Verma
Department of Neurosciences

Undergraduate Research Opportunity Description

Project Description	Following a stroke, a surge of ATP is released from compromised brain cells. This surge, in turn, triggers a cascade of events, including the activation of neurons and microglial purinergic receptor P2X4 (P2X4R). This activation facilitates rapid excitatory neurotransmission through the influx of cations. However, excessive activation of P2X4R can lead to the release of several pro-inflammatory cytokines during the initial stages of ischemic injury. Interestingly, the effects of acute activation stand in contrast to those observed with chronic inhibition or the absence of this receptor. In fact, prolonged inhibition or the lack of P2X4R might hinder the process of stroke recovery. Thus, acknowledging the dual role of P2X4R in different phases of ischemic injury, we are currently engaged in a systematic exploration of its potential as a therapeutic target for enhancing post-stroke recovery. In essence, our research endeavors revolve around deciphering the intricate role of P2X4R, recognizing its potential as a double-edged sword in stroke-induced processes. Through a comprehensive understanding of its temporal dynamics, we aim to pave the way for innovative therapeutic interventions that can tip the balance in favor of improved recovery outcomes.
Project Direction	Verma Lab focuses on the identification, validation, and development of novel drug targets and candidate drugs for treating ischemic stroke. Our research takes place in both clinical and pre-clinical settings, aiming to bridge the gap between laboratory insights and real-world impact. Our lab is dedicated to advancing our understanding of ischemic stroke by creating new animal models that mimic stroke injury and recovery processes. These models serve as essential tools for uncovering insights into the complexities of stroke-related issues. At Verma Lab, we are committed to the meticulous work of scientific exploration, aiming to contribute meaningfully to the field of stroke research
Mentorship and Supervision	Student will work with lab members (Postdoc, research assistant) and progress will be determined by PI during lab meetings or 1:1 meetings. Will provide feedback both in lab meetings and 1:1 meetings.
Student Qualifications	General understanding of laboratory work and biochemical analysis. Most important requirement is interest and motivation for neuro-vascular research.
Summer Schedule Options	Monday-Friday 9 am through 5:30 pm
Project Continuation	Fall 2024, Spring 2025
Academic Year Time Commitment	6-9 hours/week
Possible Thesis Project	Yes

Application

Submit an online application for this research opportunity at https://quest.uconn.edu/prog/HRP24-37. The application deadline is Monday, January 29, 2024.

This application requires a Resume or CV, Minimum Science GPA of 3.0, Statement of Qualifications, and Statement of Research Interest. References should be available upon request.