Project Mentor
Dr. Xiaoyan Guo
Department of Department of genetics and genome sciences
Undergraduate Research Opportunity Description
| Project Description | The accumulation of dysfunctional mitochondria is closely linked to various diseases, including neurodegenerative disorders. Our lab focuses on uncovering the molecular and cellular mechanisms that maintain mitochondrial health. One key mechanism is mitophagy—the selective degradation of damaged mitochondria. Using CRISPR-based genetic screening, we have identified candidate genes involved in this process. This summer project offers students an exciting opportunity to investigate these genes and explore their roles in regulating mitochondrial health. |
| Project Direction | Once the functional roles of the genetic hits in regulating mitophagy are validated, students will have the opportunity to continue with molecular mechanistic studies beyond the summer. |
| Mentorship and Supervision | The summer student will receive direct mentorship from both the Principal Investigator (PI) and a graduate student in the lab. Daily meetings will be held to discuss the project, review relevant papers, and provide hands-on training in technical skills. The student will also have the opportunity to present their work at lab meetings, where constructive feedback will be offered through regular, daily interactions. |
| Student Qualifications | Students with a strong interest in molecular and cellular biology are highly recommended to join our lab. |
| Summer Schedule Options | Research Dates: May 19 to July 25, 2025 Schedule: Monday-Friday 8hrs-9hrs |
| Project Continuation | Fall 2025, Spring 2026 |
| Academic Year Time Commitment | 6 hours/week |
| Possible Thesis Project | Yes |
Application
Submit an online application for this research opportunity at https://quest.uconn.edu/prog/HRPSU25-13. The application deadline is Monday, February 17, 2025.
This application requires a cover letter, a resume or CV, an unofficial transcript, GPA minimum of 3.0 and science GPA minimum of 3.0, a brief statement of research interests, and a brief statement of career interests. References should be available upon request.