Project Mentor
Dr. Zhichao Fan
Department of Immunology
Undergraduate Research Opportunity Description
| Project Description | Due to the limitation of the detection method, the dynamic changes of immune cells, such as neutrophils, monocytes, or lymphocytes, during inflammatory diseases is unclear. In vivo flow cytometry (IVFC) is a novel non-invasive diagnostic technique to quantify specific circulating cells in mice. By using IVFC, we can access the dynamics of immune cells during inflammatory diseases, such as LPS-induced systematic inflammation or lung inflammation. This project is suitable for undergraduate research since all experimental setups (mice, equipment, reagents, protocols) are established. |
| Project Direction | This is the first exploration of immune cell dynamics during inflammation. Future studies may involve different infectious or inflammatory disease models, such as lung infections, heart attack, or cancer. |
| Mentorship and Supervision | We will train all experimental techniques hand-by-hand, such as mouse handling, disease model establishment, and the use of intravital microscopy. After training, the PI will routinely meet with the student once a week to oversee the project progress. Moreover, the student will be able to ask for help from the PI when he/she meets a problem. The PI will discuss the method of data analysis with the student. A manuscript might be written and published after the summer project. |
| Student Qualifications | Enthusiasm to study new techniques and microscopy, willingness to handle experimental mice, and talents in new ideas of data processing. |
| Summer Schedule Options | Research Dates: May 24 to July 30, 2021* Schedule: M-F, 9am-5pm *This opportunity cannot be pursued virtually and may be cancelled if there are pandemic-related restrictions on research for summer 2021. |
| Project Continuation | Fall 2021, Spring 2022 |
| Academic Year Time Commitment | 3-9 hours/week |
| Possible Thesis Project | Yes |
Application
Submit an online application for this research opportunity at https://quest.uconn.edu/prog/HRP21-11. The application deadline is Monday, February 1, 2021.
This application requires a cover letter, a resume or CV, an unofficial transcript, and a brief statement of career interests.