Project Mentor

Dr. Bruce Mayer 
Department of Genetics and Genome Sciences

Undergraduate Research Opportunity Description

Project Description	We have developed computational models that describe B cell receptor signaling, which is dysregulated in human leukemias such as Chronic Lymphocytic Leukemia (CLL). We have also found patterns of protein phosphorylation (which we term “SH2 profiles”) in CLL patient samples that correlate with clinical outcomes such as disease progression. The goal of the proposed project is testing and validation of the computational model. This will involve both computational work, and biochemical studies using cell lines and patient tumor samples.
Project Direction	The overall objective of the project is to develop new workflows that combine computational modeling and biochemical markers (“biomarkers”) that predict clinical outcomes in cancer. We propose that modeling will provide insight into why a particular biomarker is correlated to outcomes. If successful, this could lead to better biomarkers, and to new targets for drug treatment in cancer.
Mentorship and Supervision	I work closely with Dr. Kazuya Machida, and both of us will be available to train the student in biochemical methods, cell culture, and cancer biology. Computational work will be done in close association with colleagues in the Center for Cell Analysis and Modeling (CCAM), who have vast expertise in this area. CCAM always has a number of summer students, so there is a good critical mass and an excellent training environment. This includes weekly CCAM research in progress talks on Fridays, and opportunities for students to present their work to other trainees. Drs. Machida and I also have regular joint lab meetings with Ji Yu’s group, which studies cell signaling using super-resolution imaging methods.
Student Qualifications	The student should have at least basic programming skills, and should have some familiarity with biochemistry.
Summer Schedule Options	Research Dates: May 26 to July 31, 2020 Schedule: M-F, 9am-5pm
Project Continuation	Fall 2020, Spring 2021
Academic Year Time Commitment	6  hours/week
Possible Thesis Project	Yes

Application

Submit an online application for this research opportunity at https://quest.uconn.edu/prog/HRP20-18. The application deadline is Monday, February 3, 2020.

This application requires a cover letter, a resume or CV, and a brief statement of research interests.