HRP SU20-15: Research Opportunity with Dr. Kazuya Machida

Project Mentor

Dr. Kazuya Machida

Department of Genetics and Genome Sciences

Undergraduate Research Opportunity Description

Project Description The goal for the summer is to develop a new single cell protein binding assay using advanced flow cytometry technologies. The student will a) construct a panel of labeled protein domain probes, b) validate the probes in biochemical and imaging analyses, c) and optimize the assay conditions using human lymphocytes. Together, these experiences enhance the student’s abilities for future careers.
Project Direction The work in the summer would result in a new clinical amenable SH2 profiling assay. The new assay could be utilized for the management of chronic lymphocytic leukemia in discovering predictive biomarkers, detecting molecular disease progression, and assessing targeted drug responses.
Mentorship and Supervision 1. General guidance and lab safety training on the first day
2. Project initiation meeting on the second day
3. Lab assistance and training by the PI
4. Training for laboratory record of research (lab note)
5. Weekly project meeting to monitor progress and solve troubles
6. Biweekly joint lab meeting with Dr. Bruce Mayer (Cell Signaling) and Dr. Ji Yu (Single Molecule Imaging)
7. Final presentation within the Summer Program
Student Qualifications General interests in biochemistry, molecular cell biology, immunology, pathobiology or related field. Previous laboratory experience may help but is not required.
Summer Schedule Options Research Dates: May 26 to July 31, 2020
Schedule: M-F, 10am-6pm
Project Continuation Fall 2020, Spring 2021
Academic Year Time Commitment  9 hours/week
Possible Thesis Project Yes


Submit an online application for this research opportunity at The application deadline is Monday, February 3, 2020.

This application requires a resume or CV and a brief statement of research interests.