Dr. Arthur Gunzl
Genetics and Genome Sciences
Undergraduate Research Opportunity Description
|Project Description||We work on trypanosomes which cause neglected tropical diseases (our strain is not pathogenic to humans). We are interested in how gene expression in these single cell eukaryotes is different from human cells. We have identified a number of proteins that seem to be parasite-specific gene expression factors. Project options will be to silence a gene of such a factor and analyze its effect on trypanosome viability and gene expression, or to express the factor with a tag in the parasite and determine whether it functions in a protein complex.|
|Project Direction||We have been characterizing the parasite’s transcription and RNA processing machineries, e.g. transcription factors and the spliceosome. The difficulty is that trypanosomes are so divergent from yeast and humans that many factors cannot be identified by sequence comparisons and require functional analysis. While a thorough understanding of a pathogen’s gene expression pathways will help to manage its long term control, the focus of this research is to identify factors that may be directly targeted by chemotherapy.|
|Mentorship and Supervision||
|Summer Schedule Options||Research Dates: 9-10 full-time weeks to be scheduled between May 8 and August 25, 2017
Schedule: To be determined in consultation with the selected student, within the parameters of M-F, 9am-6pm
|Project Continuation||Fall 2017, Spring 2018|
|Academic Year Time Commitment||9 hours/week|
|Possible Thesis Project||Yes|
Submit an online application for this research opportunity using the form below. The application deadline is Friday, February 24, 2017.
This application requires a a resume or CV, a brief statement of research interests, a brief statement of career interests, and contact information for 2 references.